The Next Generation in

 Cancer Therapy

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ABOUT ONCOSENX

OncoSenX is a late stage pre-clinical cancer company headquartered in Seattle, Washington. OncoSenX targets solid tumors based on transcriptional activity using a unique Proteo-Lipid Vehicle (PLV) and plasmid DNA.

 

OUR MISSION

The next generation in cancer therapies will be more targeted with less side effects. At OncoSenX we believe the battle against cancer should be fought with genetic information. Our treatment delivers a simple program that induces apoptosis in cancerous cells. Our approach is a less invasive, more precise intervention for this complex and devastating disease.  The next generation of cancer therapies has begun...

 

SCIENCE

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OUR SYSTEM

 

Our system is comprised of two main components: An untargeted non-toxic Proteo-Lipid Vehicle (PLV) and a highly targeted DNA payload.

 

CELL TARGETING

DNA plasmids encode an inducible death protein under a promoter that is active in the target cell population. We are initially targeting cells that are transcriptionally active for p53.

Cells are killed via apoptosis with caspase 9.

We can use our DNA payload to effectively implement logic gates (IF/OR/AND). This allows us to precisely target cell populations based on their genetic activity without harming adjacent cells.

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DELIVERY

Our patented Proteo-Lipid Vehicle (PLV) is the transfection agent that efficiently delivers our non-integrating DNA plasmid to cancer cells

These PLVs have been shown to be non-immunogenic, even with adjuvant, and are non-toxic at doses up to 10x expected human therapeutic dose in rodents and non-human primates.

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SAFETY

Anti-PLV antibody & neutralization assays:

  • Virtually no antibody response to PLVs in immune-competent mice, even with adjuvants

  • Neutralization requires very high antibody concentration

  • “Vaccination” against PLVs does not reduce efficacy

  • Repeat dosing is effective and well tolerated

CARPA Assays

PLVs are generally less reactive than other lipid drug formulations

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Our Partners

 

 
 
 
 
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TEAM

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MATTHEW SCHOLZ Chief Executive OfficerMatt is a co-founder of OncoSenX and serves as CEO and Chairman. A serial entrepreneur with a background in computer security and immunology, Matt is also the founder and CEO of Oisín Biotechnoligies and former …

MATTHEW SCHOLZ
Chief Executive Officer

Matt is a co-founder of OncoSenX and serves as CEO and Chairman. A serial entrepreneur with a background in computer security and immunology, Matt is also the founder and CEO of Oisín Biotechnoligies and former CEO of Immusoft, a biotech firm developing a breakthrough technology that will turn a patient's B cells into miniature drug factories. He’s a graduate of the University of Washington and a frequent speaker at the UW School of Business.

JOHN D. LEWIS, Ph.D. Chief Science OfficerDr. John Lewis the co-founder of OncoSenX and heads its cancer-fighting platform technology development and clinical research. Dr. Lewis also holds the Frank and Carla Sojonky Chair in Prostate Cancer Resear…

JOHN D. LEWIS, Ph.D.
Chief Science Officer

Dr. John Lewis the co-founder of OncoSenX and heads its cancer-fighting platform technology development and clinical research. Dr. Lewis also holds the Frank and Carla Sojonky Chair in Prostate Cancer Research at the University of Alberta. He is a Professor in the Department of Oncology and chairs the Alberta Prostate Cancer Research Initiative. Dr. Lewis has also founded three Canadian biotechnology companies.

GARY C. HUDSON Board MemberGary Hudson is co-founder and Board Member of OncoSenX. Mr. Hudson is also active in several non-profits focusing on age-related disease. Mr. Hudson has won several awards during his career including Laurel Award from Avia…

GARY C. HUDSON
Board Member

Gary Hudson is co-founder and Board Member of OncoSenX. Mr. Hudson is also active in several non-profits focusing on age-related disease. Mr. Hudson has won several awards during his career including Laurel Award from Aviation Week and Space Technology, the Founder’s Award from the Space Frontier Foundation and was inducted into the International Space Hall of Fame in 2014 for his contributions to the field.

 
 
ERIC GARCIA Chief Operating OfficerEric Garcia is the Chief Operating Officer and Treasurer of OncoSenX. He has responsibility for the company’s finances and business operations. Mr. Garcia also helped start Oisin Biotechnologies, serving as its COO…

ERIC GARCIA
Chief Operating Officer

Eric Garcia is the Chief Operating Officer, Treasurer and co-founder of OncoSenX. He has responsibility for the company’s finances and business operations. Mr. Garcia also helped start Oisin Biotechnologies, serving as its COO. Prior to Oisin Biotechnologies Mr. Garcia was the Chief Financial Officer for the immunotherapy biotech, Immusoft Corporation. Outside biotechnology, Mr. Garcia has worked in financial management and public policy.

Jailal Ablack, PhD Head Of Preclinical ResearchJai received his Ph.D. in Microbiology and Immunology from the University of Western Ontario in 2011 with a research focus in viral oncology. Jai relocated to San Diego to Post- Doc in the Department of…

Jailal Ablack, PhD
Head Of Preclinical Research

Jai received his Ph.D. in Microbiology and Immunology from the University of Western Ontario in 2011 with a research focus in viral oncology. Jai relocated to San Diego to Post- Doc in the Department of Medicine at UCSD expanding his interests to include mechanisms of cancer proliferation control and cancer therapeutics. In 2019, Jai joined OncoSenX to helm their pre-clinical research program.

Hank Garcia, PhD Senior ScientistHank received his Ph.D. in Cancer Genetics and Cellular and Molecular Biology from the Roswell Park Cancer Institute in 2014 with a research focus on drug development and tumor initiation. Hank then took a position a…

Hank Garcia, PhD
Senior Scientist

Hank received his Ph.D. in Cancer Genetics and Cellular and Molecular Biology from the Roswell Park Cancer Institute in 2014 with a research focus on drug development and tumor initiation. Hank then took a position as a Post-Doc in the Department of Anatomy at the University of California San Francisco, expanding his research expertise to include neurobiology and aging therapies. Hank now supports OncoSenX’s R&D efforts.

STEPHEN HILBERT Chief Business OfficerMr. Hilbert is the Chief Business Officer for OnocoSenX. He has served as business advisor since its inception and has served on several biotechnology company advisory boards specializing in business strategy an…

STEPHEN HILBERT
Chief Business Officer

Mr. Hilbert is the Chief Business Officer for OnocoSenX. He has served as business advisor since its inception and has served on several biotechnology company advisory boards specializing in business strategy and capital formation. Prior to OncoSenX in the Biotech space, Mr. Hilbert has served as corporate advisor to Immusoft and Kineta where he most recently served as VP of Corporate Development. His career spans over 10 years in biotech advisory and 18 years in the banking where he served as Vice President creating investment strategies and structures for accredited investors around the globe at JP Morgan and Charles Schwab.

 

NEWS

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CORPORATE HEADQUARTERS

701 Fifth Ave, Suite 4200

Seattle, Washington 98104

 
 

 

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